Figure 410

Rate of an enzyme-catalyzed reaction as a function of substrate concentration.

Vander et al.: Human Physiology: The Mechanism of Body Function, Eighth Edition

Protein Activity and Cellular Metabolism CHAPTER FOUR

Enzyme concentration 2A —v

Enzyme concentration A —x

— Saturation

Substrate concentration

Heterotrophic Allosteric Enzymes

Substrate concentration


At a constant substrate concentration, increasing the affinity of an enzyme for its substrate by allosteric or covalent modulation increases the rate of the enzyme-mediated reaction. Note that increasing the enzyme's affinity does not increase the maximal rate of the enzyme-mediated reaction.

Substrate concentration

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