Figure 145
Human Anatomy And Physiology Premium Course
Classes of blood cells.
Vander et al.: Human Physiology: The Mechanism of Body Function, Eighth Edition
Circulation CHAPTER FOURTEEN
Circulation CHAPTER FOURTEEN
|
Name |
Stimulates Progenitor Cells Leading to: |
|
Erythropoietin | |
|
Colony-stimulating factors (CSFs) (example: granulocyte CSF) |
Granulocytes and monocytes |
|
Interleukins (example: interleukin 3) |
Various leukocytes |
|
Thrombopoietin |
Platelets (from megakaryocytes) |
|
Stem cell factor |
Many blood-cell types |
process. Finally, in several cases the HGFs not only stimulate differentiation and proliferation of progenitor cells, they inhibit the usual programmed death (apoptosis, Chapter 7) of these cells.
The administration of specific HGFs is proving to be of considerable clinical importance. Examples are the use of erythropoietin in persons having a deficiency of this hormone due to kidney disease, and the use of granulocyte colony stimulating factor (G-CSF) to stimulate granulocyte production in individuals whose bone marrow has been damaged by anticancer drugs.
Pluripotent hematopoietic stem cell
Erythrocyte t
Lymphocyte «
Erythrocyte
Megakaryocyte
FIGURE 14-6
Production of blood cells by the bone marrow. For simplicity, no attempt has been made to differentiate the appearance of the various precursors.
Adapted form Golde and Gasson.
Platelets
Megakaryocyte
FIGURE 14-6
Production of blood cells by the bone marrow. For simplicity, no attempt has been made to differentiate the appearance of the various precursors.
Adapted form Golde and Gasson.
PART THREE Coordinated Body Functions
Vander et al.: Human Physiology: The Mechanism of Body Function, Eighth Edition
PART THREE Coordinated Body Functions
SECTION A SUMMARY
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