Figure 145

Classes of blood cells.

Vander et al.: Human Physiology: The Mechanism of Body Function, Eighth Edition

Circulation CHAPTER FOURTEEN

Circulation CHAPTER FOURTEEN

TABLE 14-4 Reference Table of Major Hematopoietic Growth Factors (HGFs)

Name

Stimulates Progenitor Cells Leading to:

Erythropoietin

Erythrocytes

Colony-stimulating factors (CSFs) (example: granulocyte CSF)

Granulocytes and monocytes

Interleukins (example: interleukin 3)

Various leukocytes

Thrombopoietin

Platelets (from megakaryocytes)

Stem cell factor

Many blood-cell types

process. Finally, in several cases the HGFs not only stimulate differentiation and proliferation of progenitor cells, they inhibit the usual programmed death (apoptosis, Chapter 7) of these cells.

The administration of specific HGFs is proving to be of considerable clinical importance. Examples are the use of erythropoietin in persons having a deficiency of this hormone due to kidney disease, and the use of granulocyte colony stimulating factor (G-CSF) to stimulate granulocyte production in individuals whose bone marrow has been damaged by anticancer drugs.

Pluripotent hematopoietic stem cell

Lymphocyte «

Erythrocyte t

Lymphocyte «

Erythrocyte

Granulocyte

Megakaryocyte

FIGURE 14-6

Production of blood cells by the bone marrow. For simplicity, no attempt has been made to differentiate the appearance of the various precursors.

Adapted form Golde and Gasson.

Platelets

Megakaryocyte

FIGURE 14-6

Production of blood cells by the bone marrow. For simplicity, no attempt has been made to differentiate the appearance of the various precursors.

Adapted form Golde and Gasson.

PART THREE Coordinated Body Functions

Vander et al.: Human Physiology: The Mechanism of Body Function, Eighth Edition

PART THREE Coordinated Body Functions

SECTION A SUMMARY

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

Get My Free Ebook


Post a comment