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Endothelial Cells Can Release Chemicals That Cause Relaxation or Constriction of Arterioles

An important contributor to local vascular regulation is released by endothelial cells. This substance, endothelium-derived relaxing factor EDRF , is released from all arteries, microvessels, veins, and lymphatic endothelial cells. EDRF is nitric oxide NO , which is formed by the action of nitric oxide synthase on the amino acid arginine. NO causes the relaxation of vascular smooth muscle by inducing an increase in cyclic guanosine monophosphate cGMP . When cGMP is increased, the smooth muscle...

The Microvasculature of Intestinal Villi Has a High Blood Flow and Unusual Exchange Properties

The intestinal mucosa receives about 60 to 70 of the total intestinal blood flow. Blood flows of 70 to 100 mL min per 100 g in this specialized tissue are probable and much higher than the average blood flow for the total intestinal wall see Table 17.1 . This blood flow can exceed the resting blood flow in the heart and brain. The mucosa is composed of individual projections of tissue called villi. The interstitial space of the villi is mildly hyperosmotic 400 mOsm kg H2O at rest as a result of...

Blood flows from right heart to lungs to left heart to body

Heart Pressure Left Right Ventricle

Let's follow the circulation of the blood through the heart, starting in the right heart. The right atrium receives deoxy-genated blood from the superior upper vena cava and the inferior lower vena cava see Figure 49.3 , large veins that collect blood from the upper and lower body, respectively. contract, the atrioventricular valves close, and pressure in the ventricles builds up until the aortic and pulmonary valves open. 3 Blood is pumped out of the ventricles and into the aorta and pulmonary...

Cutaneous Blood Flow

Increased Blood Flow The Brain

The skin is the outer covering of the body and as such serves as the first line of defense against invasion by disease-causing organisms. The skin, as the interface between the internal and external environments, also helps to maintain a constant deep-body temperature despite changes in the ambient external temperature a process called thermoregulation. The thinness and large area of the skin 1.0 to 1.5 mm thick 1.7 to 1. Describe blood flow and oxygen delivery to the myocardium during systole...

Test Your Knowledge ofTerms and F

According to the Frank-Starling Law of the Heart, the strength of ventricular contraction is a. directly proportional to the end-diastolic volume. b. inversely proportional to the end-diastolic volume. c. independent of the end-diastolic volume. 2. In the absence of compensations, the stroke volume will decrease when d. arterial blood pressure increases. 3. Which of these statements about tissue fluid is false a. It contains the same glucose and salt concentration as plasma. b. It contains a...

Clinical Aspects of the Male Reproductive System

Transurethral Incision The Prostate

Most infections of the male reproductive tract are sexually transmitted diseases STDs , listed in Display 14-1. The most common STD in the United States is caused by the bacterium Chlamydia trachomatis, which, in males, mainly causes urethritis. This same organism also causes lymphogranuloma venereum, an STD associated with lymphadenopathy, which is rare in the United States. Both forms of these chlamydial infections respond to treatment with antibiotics. Gonorrhea is caused by Neisseria...

Clinical Features Of Klinefelters Syndrome

Klinefelter Syndrome

The clinical manifestations of KS are those of prepubertal androgen deficiency and infertility. Because testicular failure occurs before puberty, the developmental changes Fig. 2. An individual with Klinefelter's syndrome. Note tall body proportions, gynecomastia, relative paucity of facial and body hair, and small testis. Photos courtesy of Dr. C. Alvin Paulsen. Fig. 2. An individual with Klinefelter's syndrome. Note tall body proportions, gynecomastia, relative paucity of facial and body...

Extrinsic Regulation of Blood Flow

Renal Circulation

The term extrinsic regulation refers to control by the autonomic nervous system and endocrine system. Angiotensin II, for example, directly stimulates vascular smooth muscle to produce generalized vasoconstriction. Antidiuretic hormone ADH also has a vasoconstrictor effect at high concentrations this is why it is also called vasopressin. This vasopressor effect of ADH is not believed to be significant under physiological conditions in humans. Stimulation of the sympathoadrenal system produces...

Explain How Valves In Veins Breathing And Skeletal Muscle Contractions Help Venous Blood Return To The Heart

Skeletal Muscle Squeezing Vein

Most of the total blood volume is contained in the venous system. Unlike arteries, which provide resistance to the flow of blood from the heart, veins are able to expand as they accumulate additional amounts of blood. The average pressure in the veins is only 2 mmHg, compared to a much higher average arterial pressure of about 100 mmHg. These values, expressed in millimeters of mercury, represent the hydrostatic pressure that the blood exerts on the walls of the vessels. The low venous pressure...

Intrinsic Regulation of Blood Flow

Intrinsic, or built-in, mechanisms within individual organs provide a localized regulation of vascular resistance and blood flow. Intrinsic mechanisms are classified as myogenic or metabolic. Some organs, the brain and kidneys in particular, utilize these intrinsic mechanisms to maintain relatively constant flow rates despite wide fluctuations in blood pressure. This ability is termed autoregulation. If the arterial blood pressure and flow through an organ are inadequate if the organ is...

Countercurrent Multiplication

Countercurrent flow flow in opposite directions in the ascending and descending limbs and the close proximity of the two limbs allow for interaction between them. Since the concentration of the tubular fluid in the descending limb reflects the concentration of surrounding interstitial fluid, and since the concentration of this fluid is raised by the active extrusion of salt from the ascending limb, a positive feedback mechanism is created. The more salt the ascending limb extrudes, the more...

Velocity of Capillary Blood Flow

Blood Flow Velocity Capillaries

Figure 14-44 illustrates a simple mechanical model of a series of 1-cm-diameter balls being pushed down a single tube that branches into narrower tubes. Although each tributary tube has a smaller cross section than the wide tube, the sum of the tributary cross sections is three times greater than that of the wide tube. Let us assume that in the wide tube each ball moves 3 cm min. If the balls are 1 cm in diameter and they move two abreast, six balls leave the wide tube per minute and enter the...

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