Cla And Bladder Cancer

Possible

Family history of bladder cancer

Direct

Genetic predisposition

Possible

Genetic polymorphism of genes involved in detoxification of aromatic amines (NAT1/NAT2, GSTM1)

Direct when NAT2 deleted, inverse when GSTM1 deleted

Inefficient detoxification of aromatic amines with consequent increased production of carcinogenic metabolites

Possible

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