Epidemiology Of Hcvassociated Lymphoma

The etiology of NHL is poorly understood but of considerable interest because of the increasing incidence of these malignancies worldwide (30). A possible causative link between hepatotropic viruses and malignant lymphomas had been hypothesized since 1971, when an autopsy study of 814 Belgian patients with neoplastic diseases reported a significant association between cirrhosis and lymphoproliferative disorders (31). With the identification of HCV as a triggering factor of MC (20-24), its potential role in NHL was suspected (12). In 1994, HCV infection was first demonstrated in a significant percentage of Italian patients with unselected B-cell NHL, regardless of the

Table 1

Hepatitis C Virus (HCV) Infection and Lymphoproliferative Disorders (LPDs)

Prevalence of HCV infection in LPDa

Authors (ref. no.)

Country

Diagnosis

No. of Patients

% HCV+

Ferri C et al., 1994 (32)

Italy

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