Action ► Seed—astringent, nervine tonic, local stimulant, used in impotence, spermatorrhoea, urinary troubles, leucorrhoea, traditionally used for male virility. Also used in depressive neurosis. Hair on fruit— vermifuge, mild vesicant; used for diseases of liver and gallbladder. Leaf—applied to ulcers. Pod— anthelmintic. Root and fruit—spasmolytic, hypoglycaemic. Root— CNS active.
The Ayurvedic Pharmacopoeia ofIn-dia recommends the seed in impotence and paralysis agitans; the root in vaginal laxity.
The seeds contain the alkaloids, mu-cunine, mucunadine, mucunadinine, prurieninine, pruriendine and nicotine, besides beta-sitosterol, gluthione, lecithin, vernolic and gallic acids. They contain a number of bioactive substances including tryptamine, alky-lamines, steroids, flavonoids, cou-marins and cardenolides. L-DOPA is present in the seed as well as in the stem, leaves and roots.
Major constituents of the hairs on the pod are amines such as 5-hydroxy-tryptamine (serotonin), and a prote-olytic enzyme mucuanain. (Serotonin was present only in pods.)
Prurieninine slowed down heart rate, lowered blood pressure and stimulated intestinal peristalsis in experiments carried out on frogs. The spas-molysis of smooth muscles was caused by indole bases.
Seed diet produced hypoglycaemic effect in normal rats, however, such diet had insignificant effect on alloxan-treated rats.
There is some evidence that Cow-hage might be useful for chlorproma-zine-induced hyperprolactinemia in men. (Natural Medicines Comprehensive Database, 2007.) (Males with hy-
Murraya koenigii (Linn.) Spreng. 425
perprolactinemia frequently face im-potency.) (Cured seeds are used in Indian medicine for male sexual dysfunction.)
Mucuna cochinchinensis Cheval.; synonym M. nivea (Roxb.) DC.; Sti-zolobium niveum Kuntze (cultivated in Bengal and Bihar for edible pods and seeds) is known as Lyon Bean (Khamach in Bengal). The pod yielded L-DOPA (0.06%).
Dosage ► Cured seed—3-6 g (API, Vol. III); root—3-6 g powder for decoction (API, Vol. IV.)
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