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Acetyl-CoA exported

NADH exported

Acetyl-CoA exported

FIGURE 17-13 Comparison of 5 oxidation in mitochondria and in peroxisomes and glyoxysomes. The peroxisomal/glyoxysomal system differs from the mitochondrial system in two respects: (1) in the first oxidative step electrons pass directly to O2, generating H2O2, and (2) the NADH formed in the second oxidative step cannot be reoxi-dized in the peroxisome or glyoxysome, so reducing equivalents are exported to the cytosol, eventually entering mitochondria. The acetyl-CoA produced by peroxisomes and glyoxysomes is also exported; the acetate from glyoxysomes (organelles found only in germinating seeds) serves as a biosynthetic precursor (see Fig. 17-14). Acetyl-CoA produced in mitochondria is further oxidized in the citric acid cycle.

oxidize very-long-chain fatty acids, apparently for lack of a functional transporter for these fatty acids in the peroxisomal membrane. Both defects lead to accumulation in the blood of very-long-chain fatty acids, especially 26:0. XALD affects young boys before the age of 10 years, causing loss of vision, behavioral disturbances, and death within a few years. ■

In mammals, high concentrations of fats in the diet result in increased synthesis of the enzymes of peroxi-somal ß oxidation in the liver. Liver peroxisomes do not contain the enzymes of the citric acid cycle and cannot catalyze the oxidation of acetyl-CoA to CO2. Instead,

17.2 Oxidation of Fatty Acids

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