Hormonal Regulation of Fuel Metabolism

Type 2 Diabetes Defeated

Natural Treatment for Diabetes Found

Get Instant Access

The minute-by-minute adjustments that keep the blood glucose level near 4.5 mm involve the combined actions of insulin, glucagon, epinephrine, and cortisol on metabolic processes in many body tissues, but especially in liver, muscle, and adipose tissue. Insulin signals these tissues that blood glucose is higher than necessary; as a result, cells take up excess glucose from the blood and convert it to the storage compounds glycogen and tria-cylglycerol. Glucagon signals that blood glucose is too low, and tissues respond by producing glucose through glycogen breakdown and (in liver) gluconeogenesis and by oxidizing fats to reduce the use of glucose. Epi-nephrine is released into the blood to prepare the muscles, lungs, and heart for a burst of activity. Cortisol mediates the body's response to longer-term stresses. We discuss these hormonal regulations in the context of three normal metabolic states—well-fed, fasted, and starving—and look at the metabolic consequences of diabetes mellitus, which results from derangements in the signaling pathways that control glucose metabolism.

Was this article helpful?

0 0
Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment