Insulin Pathway

ganglia (Fig. 6.2) [11, 57, 110, 111]. IGF-I-induced cell proliferation and Fos/Jun expression are blocked by anti-IPG antibodies, and blockage is rescued by the addition of rat liver purified IPG-A or a myo-inositol-containing analogue [11, 57].

In summary, the activation of tyrosine kinase receptors induces the hydrolysis of GPI and the concomitant release of IPG, the mechanisms by which these two

Ipg Insulin Pathway

Fig. 6.3 Insulin signaling pathways. Possible routes through which insulin can promote its diverse biological actions: Cell proliferation, gluconeogenesis, lipolysis and glycogen syn-

thesis. Arrows imply facilitating actions whereas crossbars indicate inhibitory ones. The asterisk represents the target molecules for IPG.

Fig. 6.3 Insulin signaling pathways. Possible routes through which insulin can promote its diverse biological actions: Cell proliferation, gluconeogenesis, lipolysis and glycogen syn-

thesis. Arrows imply facilitating actions whereas crossbars indicate inhibitory ones. The asterisk represents the target molecules for IPG.

early events couple within membrane compartments are currently under study. IPG modulates the intracellular levels and/or activation of nodal signaling molecules, the general protein phosphorylation state of the cell and the levels of cy-clins and transcription factors, leading in a cell type-specific manner to the regulation of metabolism homeostasis and to cellular proliferation (Fig. 6.3).

Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

Get My Free Ebook


Post a comment