Human endogenous retroviruses and multiple sclerosis

Several HERVs (-W, -K, -H) and multiple pathogenic mechanisms have been described in association with MS 14 . Studies on RNA associated with viral particles in leptomeningeal, choroids plexus or B-lymphocyte cultures from patients who have multiple sclerosis have found sequences corresponding to overlapping regions of a retroviral genome that was named MSRV (multiple sclerosis-associated retrovirus virions) 36 . MSRV has genetically high homologous counterparts in normal human DNA, the HERV-W...

Human endogenous retroviruses and systemic lupus erythematosus

A role of retroviruses in SLE pathogenesis is supported by an increasing body of evidence. A possible retroviral link with SLE was suspected initially because of the similarity of autoimmune manifestations and immune dysregulation between patients who have SLE and those infected with known human retroviruses, such as HIV-1. It has been shown that one third of patients who have SLE produce high-titer antibodies to various retroviral proteins, including Gag, Env, and Nef, and the p24 capsid...

Ines Colmegna MDa Robert F Garry PhDb

ASection of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA bDepartment of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA Definition and characteristics of human endogenous retroviruses The human genome sequencing project and similar initiatives for other species have revealed that a large portion of vertebrate genomic DNA consists of...

References

Expression and functions of human endogenous retroviruses in the placenta an update. Placenta 2004 18 S16-25. 2 Nelson PN, Carnegie PR, Martin J, et al. Demystified. Human endogenous retroviruses. Mol Pathol 2003 56 11-8. 3 Lower R, Lower J, Kurth R. The viruses in all of us characteristics and biological significance of human endogenous retrovirus sequences. Proc Natl Acad Sci USA 1996 93 5177-84. 4 Mi S, Lee X, Li X, et al. Syncytin is a captive retroviral...

Furuncles and carbuncles

Furuncles ie, boils are single hair follicle-associated inflammatory nodules extending into the dermis and the subcutaneous tissue, usually affecting moist, hairy, friction-prone areas of the body, such as the face, axillae, neck, and buttocks. Firm and tender, these nodular erythematous lesions may spontaneously drain purulent material. Fever and other constitutional symptoms rarely are present. The most common causative microorganism is S aureus, but the microbiology of furuncles depends on...

Fred A Lopez MD Serge Lartchenko MD

Section of Infectious Diseases, Department of Internal Medicine, Louisiana State University Health Sciences Center, Box E7-17, 2020 Gravier Street, New Orleans, LA 70112, USA Primary skin infections ie, pyodermas typically are initiated by some breach in the epidermis, resulting in infection by organisms, such as Streptococcus pyogenes and Staphylococcus aureus, that colonize the skin. Host-associated factors, such as immunosuppression, vasculopathy, neuropathy, or decreased lymphatic drainage,...